Publications

2019

Mammoto A and Mammoto T. Vascular niche in lung alveolar development, homeostasis and regeneration. Front. Bioeng. Biotech. 7 318 2019.

Mammoto T, Torisawa YS, Muyleart M, Hendee K, Anugwom C, Gutterman D, Mammoto A. Effects of age dependent changes in cell size on endothelial cell proliferation and senescence through YAP1. Aging (Albany NY). 2019 5; 11(17) 7051-7069. doi: 10.18632/aging.102236.

Papa AL, Jiang A, Korin N, Chen MB, Langan ET, Waterhouse A, Nash E, Caroff J, Graveline A, Vernet A, Mammoto AMammoto T, Jain A, Kamm RD, Gounis MJ, Ingber DE. Platelet decoys inhibit thrombosis and prevent metastatic tumor formation in preclinical models. Sci Transl Med. 2019 Feb 13;11(479). doi: 10.1126/scitranslmed.aau5898. PMID: 30760580

Mammoto A Muyleart MMammoto T. LRP5 in age-related changes in vascular and alveolar morphogenesis in the lung. Aging (Albany NY) 2019 Jan 5; 11: 89-103. doi: 10.18632/aging.101722. [Epub ahead of print]

Mammoto TMuyleart MMammoto A. Endothelial YAP1 in Regenerative Lung Growth through the Angiopoietin-Tie2 Pathway. Am J Respir Cell Mol Biol. 2018 60(1): 117-1127. doi: 10.1165/rcmb.2018-0105OC.

2018

Mammoto A, Muyleart M, Kadlec A, Gutterman D, Mammoto T. YAP1-Tead1 signaling controls angiogenesis and mitochondrial biogenesis through PGC1a. Microvasc Res. 2018 119: 73-83. PMID: 29875901, doi: 10.2185/jrm.2962. May 2018

Jalili-Firoozinezhad S, Prantil-Baun R, Jiang A, Potla R, Mammoto T, Weaver JC, Ferrante TC, Kim HJ, Cabral JMS, Levy O, Ingber DE. Modeling radiation injury-induced cell death and countermeasure drug responses in a human Gut-on-a-Chip. Cell Death Dis. 2018 Feb 14;9(2):223. PMID: 29445080 DOI:10.1038/s41419-018-0304-8, Feb 2018

Mammoto T, Muyleart M, Konduri GG, Mammoto A. Twist1 in Hypoxia-induced Pulmonary Hypertension Through TGFβ-Smad Signaling. Am J Respir Cell Mol Biol. 2018 Feb; 58 (2): 194-207. doi: 10.1165/rcmb.2016-0323OC. Feb 2018

Sulciner ML, Serhan CN, Gilligan MM, Mudge DK, Chang J, Gartung A, Lehner KA, Bielenberg DR, Schmidt B, Dalli J, Greene ER, Gus-Brautbar Y, Piwowarski J, Mammoto T, Zurakowski D, Perretti M, Sukhatme VP, Kaipainen A, Kieran MW, Huang S, Panigrahy D. Resolvins suppress tumor growth and enhance cancer therapy. J Exp Med. 2018 215 (1): 115-140. doi: 10.1084/jem.20170681. [Epub ahead of print], Jan 2018

2017

Musah S, Mammoto A, Ferrante TC, Jeanty SSF, Hirano-Kobayashi M, Mammoto T, Roberts K, Chung S, Novak R, Ingram M, Fatanat-Didar T, Koshy S, Weaver JC, Church GM, Ingber DE. Mature induced-pluripotent-stem-cell-derived human podocytes reconstitute kidney glomerular-capillary-wall function on a chip. Nat Biomed Eng. 2017;1. pii: 0069. doi: 10.1038/s41551-017-0069. Epub 2017 May 10. PMID:29038743, May 2017

Hashmi B, Mammoto T, Weaver J, Ferrante T, Jiang A, Jiang E, Feliz J, Ingber DE. Mechanical induction of dentin-like differentiation by adult mouse bone marrow stromal cells using compressive scaffolds. Stem Cell Res. 2017 Aug 17;24:55-60. doi: 10.1016/j.scr.2017.08.011. PMID: 28841424, Aug 2017

Papa AL, Korin N, Kanapathipillai M, Mammoto AMammoto T, Jiang A, Mannix R, Uzun O, Johnson C, Bhatta D, Cuneo G, Ingber DE. Ultrasound-sensitive nanoparticle aggregates for targeted drug delivery. Biomaterials. 2017 Sep;139:187-194. doi: 10.1016/j.biomaterials.2017.06.003.PMID: 28618348

Jain A, Barrile R, van der Meer AD, Mammoto A, Mammoto T, De Ceunynck K, Aisiku O, Otieno MA, Louden CS, Hamilton GA, Flaumenhaft R, Ingber DE. A primary human lung alveolus-on-a-chip model of intravascular thrombosis for assessment of therapeutics. Clin Pharmacol Ther 2018 May 103 (2): 332-340. doi: 10.1002/cpt.742. PMID: 28516446

Mahmoud MM, Serbanovic-Canic J, Feng S, Souilhol C, Xing R, Hsiao S, Mammoto A, Chen J, Ariaans M, Francis SE, Van der Heiden K, Ridger V, Evans PC. Shear stress induces endothelial-to-mesenchymal transition via the transcription factor Snail. Sci Rep. 2017 Jun 13;7(1):3375. PMID: 28611395. PMCID:PMC5469771

2016

Mammoto T, Jiang A, Jiang E, Mammoto A. Role of Twist1 Phosphorylation in Angiogenesis and Pulmonary Fibrosis. Am J Respir Cell Mol Biol 2016 Nov;55(5):633-644 PMID: 27281171

Mammoto T, Chen Z, Jiang A, Jiang E, Ingber DE, Mammoto A. Acceleration of Lung Regeneration by Platelet-Rich Plasma Extract through the Low-Density Lipoprotein Receptor-Related Protein 5-Tie2 Pathway. Am J Respir Cell Mol Biol 2016 Jan;54(1):103-13 PMID: 26091161 PMCID: PMC5455682

Torisawa YS, Mammoto T, Jiang E, Jiang A, Mammoto A, Watters AL, Bahinski A, Ingber DE. Modeling Hematopoiesis and Responses to Radiation Countermeasures in a Bone Marrow-on-a-Chip. Tissue Eng Part C Methods 2016 May;22(5):509-15 PMID: 26993746

Mahmoud MM, Kim HR, Xing R, Hsiao S, Mammoto A, Chen J, Serbanovic-Canic J, Feng S, Bowden NP, Maguire R, Ariaans M, Francis SE, Weinberg PD, van der Heiden K, Jones EA, Chico TJ, Ridger V, Evans PC . TWIST1 Integrates Endothelial Responses to Flow in Vascular Dysfunction and Atherosclerosis. Circ Res2016 Jul 22;119(3):450-62 PMID: 27245171 PMCID: PMC4959828

2015

Mammoto T, Mammoto A, Jiang A, Jiang E, Hashmi B, Ingber DE. Mesenchymal condensation-dependent accumulation of collagen VI stabilizes organ-specific cell fates during embryonic tooth formation. Dev Dyn 2015 Jun;244(6):713-23 PMID: 25715693 PMCID: PMC4449280

Mammoto T, Jiang A, Jiang E, Mammoto A. Platelet-rich plasma extract prevents pulmonary edema through angiopoietin-Tie2 signaling. Am J Respir Cell Mol Biol 2015 Jan;52(1):56-64 PMID: 24960457 PMCID: PMC5455304

Huebsch N, Lippens E, Lee K, Mehta M, Koshy ST, Darnell MC, Desai RM, Madl CM, Xu M, Zhao X, Chaudhuri O, Verbeke C, Kim WS, Alim K, Mammoto A, Ingber DE, Duda GN, Mooney DJ. Matrix elasticity of void-forming hydrogels controls transplanted-stem-cell-mediated bone formation. Nat Mater 2015 Dec;14(12):1269-77 PMID: 26366848 PMCID: PMC4654683

Yoshida A, Shimizu A, Asano H, Kadonosono T, Kondoh SK, Geretti E, Mammoto A, Klagsbrun M, Seo MK. VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells. Biol Open 2015 Jul 24;4(9):1063-76 PMID: 26209534 PMCID: PMC4582117

Didar TF, Cartwright MJ, Rottman M, Graveline AR, Gamini N, Watters AL, Leslie DC, Mammoto T, Rodas MJ, Kang JH, Waterhouse A, Seiler BT, Lombardo P, Qendro EI, Super M, Ingber DE. Improved treatment of systemic blood infections using antibiotics with extracorporeal opsonin hemoadsorption. Biomaterials. 2015 Oct;67:382-92. PMID: 26253638

2014

Mammoto T, Mammoto A. Implantation of fibrin gel on mouse lung to study lung-specific angiogenesis. J Vis Exp 2014 Dec 21(94) PMID: 25548859 PMCID: PMC4396947

German AE, Mammoto T, Jiang E, Ingber DE, Mammoto A. Paxillin controls endothelial cell migration and tumor angiogenesis by altering neuropilin 2 expression. J Cell Sci 2014 Apr 15;127(Pt 8):1672-83 PMID: 24522185 PMCID: PMC3986673

Kawasaki J, Aegerter S, Fevurly RD, Mammoto A, Mammoto T, Sahin M, Mably JD, Fishman SJ, Chan J. RASA1 functions in EPHB4 signaling pathway to suppress endothelial mTORC1 activity. J Clin Invest 2014 Jun;124(6):2774-84 PMID: 24837431 PMCID: PMC4089464

Kang JH, Super M, Yung CW, Cooper RM, Domansky K, Graveline AR, Mammoto T, Berthet JB, Tobin H, Cartwright MJ, Watters AL, Rottman M, Waterhouse A, Mammoto A, Gamini N, Rodas MJ, Kole A, Jiang A, Valentin TM, Diaz A, Takahashi K, Ingber DE. An extracorporeal blood-cleansing device for sepsis therapy.  Nat Med 2014 Oct;20(10):1211-6 PMID: 25216635

Torisawa YS, Spina CS, Mammoto T, Mammoto A, Weaver JC, Tat T, Collins JJ, Ingber DE. Bone marrow-on-a-chip replicates hematopoietic niche physiology in vitro. Nat Methods 2014 Jun;11(6):663-9 PMID: 24793454

Hashmi B, Zarzar LD, Mammoto T, Mammoto A, Jiang A, Aizenberg J, Ingber DE. Developmentally-inspired shrink-wrap polymers for mechanical induction of tissue differentiation. Adv Mater 2014 May 28;26(20):3253-7 PMID: 24550068 PMCID: PMC4146397

Polacheck WJ, German AE, Mammoto A, Ingber DE, Kamm RD. Mechanotransduction of fluid stresses governs 3D cell migration. Proc Natl Acad Sci U S A 2014 Feb 18;111(7):2447-52 PMID: 24550267 PMCID: PMC3932905

Akino T, Han X, Nakayama H, McNeish B, Zurakowski D, Mammoto A, Klagsbrun M, Smith E. Netrin-1 promotes medulloblastoma cell invasiveness and angiogenesis, and demonstrates elevated expression in tumor tissue and urine of patients with pediatric medulloblastoma. Cancer Res 2014 Jul 15;74(14):3716-26 PMID: 24812271 PMCID: PMC4123751

Campàs O, Mammoto T, Hasso S, Sperling RA, O’Connell D, Bischof AG, Maas R, Weitz DA, Mahadevan L, Ingber DE. Quantifying cell-generated mechanical forces within living embryonic tissues. Nat Methods. 2014 Feb;11(2):183-9. PMID: 24317254 PMCID: PMC3939080

Li J, Liu CH, Sun Y, Gong Y, Fu Z, Evans LP, Tian KT, Juan AM, Hurst CG, Mammoto A, Chen J. Endothelial TWIST1 promotes pathological ocular angiogenesis. Invest Ophthalmol Vis Sci. 2014 Nov 20;55(12):8267-77. PMID: 25414194 PMCID: PMC4541480

2013

Mammoto T, Mammoto A, Ingber DE. Mechanobiology and developmental control. Annu Rev Cell Dev Biol2013;29:27-61 PMID: 24099083

Mammoto T, Jiang E, Jiang A, Lu Y, Juan AM, Chen J, Mammoto A. Twist1 controls lung vascular permeability and endotoxin-induced pulmonary edema by altering Tie2 expression. PLoS One 2013;8(9):e73407 PMID: 24023872 PMCID: PMC3759405

Mammoto T, Jiang A, Jiang E, Panigrahy D, Kieran MW, Mammoto A. Role of collagen matrix in tumor angiogenesis and glioblastoma multiforme progression.  Am J Pathol 2013 Oct;183(4):1293-305 PMID: 23928381 PMCID: PMC3791684

Mammoto T, Jiang E, Jiang A, Mammoto A. Extracellular matrix structure and tissue stiffness control postnatal lung development through the lipoprotein receptor-related protein 5/Tie2 signaling system. Am J Respir Cell Mol Biol 2013 Dec;49(6):1009-18 PMID: 23841513

Mammoto A, Mammoto T, Kanapathipillai M, Wing Yung C, Jiang E, Jiang A, Lofgren K, Gee EP, Ingber DE Control of lung vascular permeability and endotoxin-induced pulmonary oedema by changes in extracellular matrix mechanics. Nat Commun 2013;4:1759 PMID: 23612300

Panigrahy D, Kalish BT, Huang S, Bielenberg DR, Le HD, Yang J, Edin ML, Lee CR, Benny O, Mudge DK, Butterfield CE, Mammoto A, Mammoto T, Inceoglu B, Jenkins RL, Simpson MA, Akino T, Lih FB, Tomer KB, Ingber DE, Hammock BD, Falck JR, Manthati VL, Kaipainen A, D’Amore PA, Puder M, Zeldin DC, Kieran MW. Epoxyeicosanoids promote organ and tissue regeneration. Proc Natl Acad Sci U S A 2013 Aug 13;110(33):13528-33 PMID: 23898174 PMCID: PMC3746918

Bischof AG, Yüksel D, Mammoto T, Mammoto A, Krause S, Ingber DE. Breast cancer normalization induced by embryonic mesenchyme is mediated by extracellular matrix biglycan. Integr Biol (Camb) 2013 Aug;5(8):1045-56 PMID: 23817524

Coma S, Allard-Ratick M, Akino T, van Meeteren LA, Mammoto A, Klagsbrun M. GATA2 and Lmo2 control angiogenesis and lymphangiogenesis via direct transcriptional regulation of neuropilin-2.  Angiogenesis 2013 Oct;16(4):939-52 PMID: 23892628 PMCID: PMC3793839

Levesque BM, Kalish LA, Winston AB, Parad RB, Hernandez-Diaz S, Phillips M, Zolit A, Morey J, Gupta M, Mammoto A, Ingber DE, Van Marter LJ. Low urine vascular endothelial growth factor levels are associated with mechanical ventilation, bronchopulmonary dysplasia and retinopathy of prematurity. Neonatology2013;104(1):56-64 PMID: 23711562

Shimizu A, Nakayama H, Wang P, König C, Akino T, Sandlund J, Coma S, Italiano JE Jr, Mammoto A, Bielenberg DR, Klagsbrun M. Netrin-1 promotes glioblastoma cell invasiveness and angiogenesis by multiple pathways including activation of RhoA, cathepsin B, and cAMP-response element-binding protein. J Biol Chem 2013 Jan 25;288(4):2210-22 PMID: 23195957 PMCID: PMC3554894

2012

Sero JE, German AE, Mammoto A, Ingber DE. Paxillin controls directional cell motility in response to physical cues. Cell Adh Migr 2012 Nov-Dec;6(6):502-8 PMID: 23076140 PMCID: PMC3547894

Mammoto T, Chen J, Jiang E, Jiang A, Smith LE, Ingber DE, Mammoto A. LRP5 regulates development of lung microvessels and alveoli through the angiopoietin-Tie2 pathway. PLoS One 2012;7(7):e41596 PMID: 22848540 PMCID: PMC3404972

Mammoto A, Mammoto T, Ingber DE. Mechanosensitive mechanisms in transcriptional regulation. J Cell Sci 2012 Jul 01;125 (Pt 13):3061-73 PMID: 22797927 PMCID: PMC3434847

Kanapathipillai M, Mammoto A, Mammoto T, Kang JH, Jiang E, Ghosh K, Korin N, Gibbs A, Mannix R, Ingber DE. Inhibition of mammary tumor growth using lysyl oxidase-targeting nanoparticles to modify extracellular matrix. Nano Lett 2012 Jun 13;12(6):3213-7 PMID: 22554317

Kang JH, Krause S, Tobin H, Mammoto A, Kanapathipillai M, Ingber DE. A combined micromagnetic-microfluidic device for rapid capture and culture of rare circulating tumor cells. Lab Chip 2012 Jun 21;12(12):2175-81 PMID: 22453808

O’Connell DJ, Ho JW, Mammoto T, Turbe-Doan A, O’Connell JT, Haseley PS, Koo S, Kamiya N, Ingber DE, Park PJ, Maas RL. A wnt-bmp feedback circuit controls intertissue signaling dynamics in tooth organogenesis. (2012) Sci Signal 10;5 (206): ra4 PMID: 22234613

2011

Mammoto T, Mammoto A, Torisawa YS, Tat T, Gibbs A, Derda R, Mannix R, de Bruijn M, Yung CW, Huh D, Ingber DE. Mechanochemical control of mesenchymal condensation and embryonic tooth organ formation. Dev Cell 2011 Oct 18;21(4):758-69 PMID: 21924961 PMCID: PMC3199351

Panigrahy D, Edin ML, Lee CR, Huang S, Bielenberg DR, Butterfield CE, Barnés CM, Mammoto A, Mammoto T, Luria A, Benny O, Chaponis DM, Dudley AC, Greene ER, Vergilio JA, Pietramaggiori G, Scherer-Pietramaggiori SS, Short SM, Seth M, Lih FB, Tomer KB, Yang J, Schwendener RA, Hammock BD, Falck JR, Manthati VL, Ingber DE, Kaipainen A, D’Amore PA, Kieran MW, Zeldin DC. Epoxyeicosanoids stimulate multiorgan metastasis and tumor dormancy escape in mice.  J Clin Invest 2012 Jan;122(1):178-91 PMID: 22182838 PMCID: PMC3248288

Chen J, Stahl A, Krah NM, Seaward MR, Dennison RJ, Sapieha P, Hua J, Hatton CJ, Juan AM, Aderman CM, Willett KL, Guerin KI, Mammoto A, Campbell M, Smith LE. Wnt signaling mediates pathological vascular growth in proliferative retinopathy.  Circulation 2011 Oct 25;124(17):1871-81 PMID: 21969016 PMCID: PMC3326389

Derda R, Tang SK, Laromaine A, Mosadegh B, Hong E, Mwangi M, Mammoto A, Ingber DE, Whitesides GM. Multizone paper platform for 3D cell cultures.  PLoS One 2011 May 06;6(5):e18940 PMID: 21573103 PMCID: PMC3089608

Sero JE, Thodeti CK, Mammoto A, Bakal C, Thomas S, Ingber DE. Paxillin mediates sensing of physical cues and regulates directional cell motility by controlling lamellipodia positioning. PLoS One 2011;6(12):e28303 PMID: 22194823 PMCID: PMC3237434

2010

Xu Y, Bismar TA, Su J, Xu B, Kristiansen G, Varga Z, Teng L, Ingber DE, Mammoto A, Kumar R, Alaoui-Jamali MA. Filamin A regulates focal adhesion disassembly and suppresses breast cancer cell migration and invasion.  J Exp Med 2010 Oct 25;207(11):2421-37 PMID: 20937704 PMCID: PMC2964581

Mammoto T, Ingber DE. Mechanical control of tissue and organ development.  Development 2010 May;137(9):1407-20 PMID: 20388652 PMCID: PMC2853843

Huh D, Matthews BD, Mammoto A, Montoya-Zavala M, Hsin HY, Ingber DE. Reconstituting organ-level lung functions on a chip. Science 2010 Jun 25;328(5986):1662-8 PMID: 20576885

Matthews BD, Thodeti CK, Tytell JD, Mammoto A, Overby DR, Ingber DE . Ultra-rapid activation of TRPV4 ion channels by mechanical forces applied to cell surface beta1 integrins. Integr Biol (Camb) 2010 Sep;2(9):435-42 PMID: 20725677 PMCID: PMC3147167

2009

Mammoto A, Connor KM, Mammoto T, Yung CW, Huh D, Aderman CM, Mostoslavsky G, Smith LE, Ingber DE. A mechanosensitive transcriptional mechanism that controls angiogenesis. Nature 2009 Feb 26;457(7233):1103-8 PMID: 19242469 PMCID: PMC2708674

Derda R, Laromaine A, Mammoto A, Tang SK, Mammoto T, Ingber DE, Whitesides GM. Paper-supported 3D cell culture for tissue-based bioassays.  Proc Natl Acad Sci U S A 2009 Nov 03;106(44):18457-62 PMID: 19846768 PMCID: PMC2773961

Thodeti CK, Matthews B, Ravi A, Mammoto A, Ghosh K, Bracha AL, Ingber DE. TRPV4 channels mediate cyclic strain-induced endothelial cell reorientation through integrin-to-integrin signaling.  Circ Res 2009 May 08;104(9):1123-30 PMID: 19359599 PMCID: PMC2754067

Czakó B, Kürti L, Mammoto A, Ingber DE, Corey EJ. Discovery of potent and practical antiangiogenic agents inspired by cortistatin A. J Am Chem Soc 2009 Jul 01;131(25):9014-9 PMID: 19469509

Mammoto A, Ingber DE. Cytoskeletal control of growth and cell fate switching. Curr Opin Cell Biol 2009 Dec;21(6):864-70 PMID: 19740640

2008

Mammoto A, Mammoto T, Ingber DE. Rho signaling and mechanical control of vascular development. Curr Opin Hematol 2008 May;15(3):228-34 PMID: 18391790

Mammoto A, Sero JE, Mammoto T, Ingber DE. Methods for studying mechanical control of angiogenesis by the cytoskeleton and extracellular matrix. Methods Enzymol 2008;443:227-59 PMID: 18772019

Ghosh K, Thodeti CK, Dudley AC, Mammoto A, Klagsbrun M, Ingber DE. Tumor-derived endothelial cells exhibit aberrant Rho-mediated mechanosensing and abnormal angiogenesis in vitro. Proc Natl Acad Sci U S A 2008 Aug 12;105(32):11305-10 PMID: 18685096 PMCID: PMC2516246

Shimizu A, Mammoto A, Italiano JE Jr, Pravda E, Dudley AC, Ingber DE, Klagsbrun M. ABL2/ARG tyrosine kinase mediates SEMA3F-induced RhoA inactivation and cytoskeleton collapse in human glioma cells. J Biol Chem 2008 Oct 03;283(40):27230-8 PMID: 18660502 PMCID: PMC2555994

2007

Mammoto T, Parikh SM, Mammoto A, Gallagher D, Chan B, Mostoslavsky G, Ingber DE, Sukhatme VP. Angiopoietin-1 requires p190 RhoGAP to protect against vascular leakage in vivo. J Biol Chem 2007 Aug 17;282(33):23910-8 PMID: 17562701

Chen Z, Naveiras O, Balduini A, Mammoto A, Conti MA, Adelstein RS, Ingber D, Daley GQ, Shivdasani RA. The May-Hegglin anomaly gene MYH9 is a negative regulator of platelet biogenesis modulated by the Rho-ROCK pathway.  Blood 2007 Jul 01;110(1):171-9 PMID: 17392504 PMCID: PMC1896110

Yuan HT, Venkatesha S, Chan B, Deutsch U, Mammoto T, Sukhatme VP, Woolf AS, Karumanchi SA. Activation of the orphan endothelial receptor Tie1 modifies Tie2-mediated intracellular signaling and cell survival.  FASEB J 2007 Oct;21(12):3171-83 PMID: 17504972

Mammoto A, Huang S, Ingber DE. Filamin links cell shape and cytoskeletal structure to Rho regulation by controlling accumulation of p190RhoGAP in lipid rafts. J Cell Sci 2007 Feb 01;120(Pt 3):456-67 PMID: 17227794

2006

Venkatesha S, Toporsian M, Lam C, Hanai J, Mammoto T, Kim YM, Bdolah Y, Lim KH, Yuan HT, Libermann TA, Stillman IE, Roberts D, D’Amore PA, Epstein FH, Sellke FW, Romero R, Sukhatme VP, Letarte M, Karumanchi SA. Soluble endoglin contributes to the pathogenesis of preeclampsia. Nat Med 2006 Jun;12(6):642-9 PMID:

Mammoto T, Parikh SM, Schultz A, Yuan HT, Christiani D, Karumanchi SA, Sukhatme VP Excess circulating angiopoietin-2 may contribute to pulmonary vascular leak in sepsis in humans. PLoS Med 2006 Mar;3(3):e46 PMID: 16417407 PMCID: PMC1334221

2005

Mammoto T , Hanai J, Seth P, Mori K, Karumanchi SA, Barasch J, Sukhatme VP. Lipocalin 2 diminishes invasiveness and metastasis of Ras-transformed cells. J Biol Chem 2005 Apr 08;280(14):13641-7 PMID: 15691834

2004

Feinberg MW, Watanabe M, Lebedeva MA, Depina AS, Hanai J, Mammoto T, Frederick JP, Wang XF, Sukhatme VP, Jain MK. Transforming growth factor-beta1 inhibition of vascular smooth muscle cell activation is mediated via Smad3. J Biol Chem 2004 Apr 16;279(16):16388-93 PMID: 14754879

Mammoto A, Huang S, Moore K, Oh P, Ingber DE. Role of RhoA, mDia, and ROCK in cell shape-dependent control of the Skp2-p27kip1 pathway and the G1/S transition.  J Biol Chem 2004 Jun 18;279(25):26323-30 PMID: 15096506

2003

Zeisberg M, Hanai J, Sugimoto H, Mammoto T, Charytan D, Strutz F, Kalluri R. BMP-7 counteracts TGF-beta1-induced epithelial-to-mesenchymal transition and reverses chronic renal injury. Nat Med 2003 Jul;9(7):964-8 PMID: 12808448

Nanba D, Mammoto A, Hashimoto K, Higashiyama S. Proteolytic release of the carboxy-terminal fragment of proHB-EGF causes nuclear export of PLZF.  J Cell Biol 2003 Nov 10;163(3):489-502 PMID: 14597771 PMCID: PMC2173632

Kita T, Mammoto T, Taniguchi H, Yamasaki K, Kishi Y. Diabetes attenuates the hemodynamic stabilizing effects of oral clonidine during off-pump coronary artery bypass surgery. J Clin Anesth 2003 Nov;15(7):520-4 PMID: 14698364

2002

Mammoto T, Mukai M, Mammoto A, Yamanaka Y, Hayashi Y, Mashimo T, Kishi Y, Nakamura H. Intravenous anesthetic, propofol inhibits invasion of cancer cells.  Cancer Lett 2002 Oct 28;184(2):165-70 PMID: 12127688

Mammoto T, Higashiyama S, Mukai M, Mammoto A, Ayaki M, Mashimo T, Hayashi Y, Kishi Y, Nakamura H, Akedo H. Infiltration anesthetic lidocaine inhibits cancer cell invasion by modulating ectodomain shedding of heparin-binding epidermal growth factor-like growth factor (HB-EGF). J Cell Physiol 2002 Sep;192(3):351-8 PMID: 12124780

Mukai M, Togawa A, Imamura F, Iwasaki T, Ayaki M, Mammoto T, Nakamura H, Tatsuta M, Inoue M. Sustained tyrosine-phosphorylation of FAK through Rho-dependent adhesion to fibronectin is essential for cancer cell migration.  Anticancer Res 2002 Nov-Dec;22(6A):3175-84 PMID: 12530062

Kita T, Mammoto T, Kishi Y. Fluid management and postoperative respiratory disturbances in patients with transthoracic esophagectomy for carcinoma.  J Clin Anesth 2002 Jun;14(4):252-6 PMID: 12088806

Nakata K, Mammoto T, Kita T, Taniguchi H, Kanbara N, Akamatsu T, Sakai T, Kishi Y. Continuous epidural, not intravenous, droperidol inhibits pruritus, nausea, and vomiting during epidural morphine analgesia. J Clin Anesth 2002 Mar;14(2):121-5 PMID: 11943525

Yamanaka Y, Mammoto T, Kirita T, Mukai M, Mashimo T, Sugimura M, Kishi Y, Nakamura H. Epinephrine inhibits invasion of oral squamous carcinoma cells by modulating intracellular cAMP. Cancer Lett 2002 Feb 25;176(2):143-8 PMID: 11804741

2001

Kita T, Kagawa K, Mammoto T, Takada K, Hayashi Y, Mashimo T, Kishi Y. Diabetes attenuates the minimum anaesthetic concentration (MAC) and MAC-blocking adrenergic response reducing actions of clonidine in rats.  Acta Anaesthesiol Scand 2001 Nov;45(10):1230-4 PMID: 11736675

Yamanaka Y, Mammoto T, Kita T, Kishi Y. A study of 13 patients with gastric tube in place after esophageal resection: use of omeprazole to decrease gastric acidity and volume.  J Clin Anesth 2001 Aug;13(5):370-3 PMID: 11498319

Kita T, Nakata K, Mammoto T, Kishi Y. Anesthetic management of a patient with hypertrophic obstructive cardiomyopathy after percutaneous transluminal septal myocardial ablation: early postinterventional period and anesthetic considerations.  J Cardiothorac Vasc Anesth 2001 Jun;15(3):362-3 PMID: 11426371

Nakagawa M, Mammoto T, Sakai T, Kishi Y, Mashimo T. Premedication modifies the quality of sedation with propofol during regional anesthesia.  Can J Anaesth 2001 Mar;48(3):284-7 PMID: 11305831

Naganobu K, Hagio M, Sonoda T, Kagawa K, Mammoto T. Arrhythmogenic effect of hypercapnia in ducks anesthetized with halothane.  Am J Vet Res 2001 Jan;62(1):127-9 PMID: 11197549

2000

Kita T, Kagawa K, Mammoto T, Takada K, Hayashi Y, Mashimo T, Kishi Y. Supraspinal, not spinal, alpha(2) adrenoceptors are involved in the anesthetic-sparing and hemodynamic-stabilizing effects of systemic clonidine in rats. Anesth Analg 2000 Mar;90(3):722-6 PMID: 10702464

Ayaki M, Mukai M, Imamura F, Iwasaki T, Mammoto T, Shinkai K, Nakamura H, Akedo H. Cooperation of fibronectin with lysophosphatidic acid induces motility and transcellular migration of rat ascites hepatoma cells. Biochim Biophys Acta 2000 Jan 10;1495(1):40-50 PMID: 10634931

Nakagawa M, Mammoto T, Hazama A, Kita T, Akamatsu T, Kambara N, Sakai T, Kishi Y. Midazolam premedication reduces propofol requirements for sedation during regional anesthesia. Can J Anaesth 2000 Jan;47(1):47-9 PMID: 10626718

Mammoto A, Takahashi K, Sasaki T, Takai Y. Stimulation of Rho GDI release by ERM proteins.  Methods Enzymol 2000;325:91-101 PMID: 11036595

Fujiwara T, Mammoto A, Kim Y, Takai Y. Rho small G-protein-dependent binding of mDia to an Src homology 3 domain-containing IRSp53/BAIAP2. Biochem Biophys Res Commun 2000 May 19;271(3):626-9 PMID: 10814512

Mammoto A, Sasaki T, Kim Y, Takai Y. Physical and functional interaction of rabphilin-11 with mammalian Sec13 protein. Implication in vesicle trafficking. J Biol Chem 2000 May 05;275(18):13167-70 PMID: 10747849

1999

Murakami K, Mammoto T, Kita T, Imai Y, Mashimo T, Kirita T, Sugimura M, Kishi Y. Oral clonidine reduces the requirement of prostaglandin E1 for induced hypotension. Can J Anaesth 1999 Nov;46(11):1043-7 PMID: 10566924

Mammoto A, Ohtsuka T, Hotta I, Sasaki T, Takai Y.  Rab11BP/Rabphilin-11, a downstream target of rab11 small G protein implicated in vesicle recycling. J Biol Chem 1999 Sep 03;274(36):25517-24 PMID: 10464283

Nakano K, Takaishi K, Kodama A, Mammoto A, Shiozaki H, Monden M, Takai Y.  Distinct actions and cooperative roles of ROCK and mDia in Rho small G protein-induced reorganization of the actin cytoskeleton in Madin-Darby canine kidney cells.  Mol Biol Cell 1999 Aug;10(8):2481-91 PMID: 10436006 PMCID: PMC25478

Murata K, Kameyama M, Fukui FOhigashi HHiratsuka MSasaki YKabuto TMukai MMammoto TAkedo HIshikawa OImaoka S. Phosphodiesterase type III inhibitor, cilostazol, inhibits colon cancer cell motility. Clin Exp Metastasis 1999;17(6):525-30. PMID: 10763919

Imai Y, Mammoto T, Murakami K, Kita T, Sakai T, Kagawa K, Kirita T, Sugimura M, Kishi Y. The effects of preanesthetic oral clonidine on total requirement of propofol for general anesthesia. J Clin Anesth 1998 Dec;10(8):660-5 PMID: 9873968

1998

Mammoto T, Hayashi Y, Ohnishi Y, Kuro M. Incidence of venous and paradoxical air embolism in neurosurgical patients in the sitting position: detection by transesophageal echocardiography.  Acta Anaesthesiol Scand 1998 Jul;42(6):643-7 PMID: 9689268

Takahashi K, Sasaki T, Mammoto A, Hotta I, Takaishi K, Imamura H, Nakano K, Kodama A, Takai Y. Interaction of radixin with Rho small G protein GDP/GTP exchange protein Dbl. Oncogene. 1998 Jun 25;16(25):3279-84. PMID: 9681826

1997

Mammoto A, Sasaki T, Asakura T, Hotta I, Imamura H, Takahashi K, Matsuura Y, Shirao T, Takai Y. Interactions of drebrin and gephyrin with profilin. Biochem Biophys Res Commun 1998 Feb 04;243(1):86-9 PMID: 9473484

Kagawa K, Mammoto T, Hayashi Y, Kamibayashi T, Mashimo T, Yoshiya I. The effect of imidazoline receptors and alpha2-adrenoceptors on the anesthetic requirement (MAC) for halothane in rats. Anesthesiology1997 Oct;87(4):963-7 PMID: 9357900

Takahashi K, Sasaki T, Mammoto A, Takaishi K, Kameyama T, Tsukita S, Takai Y. Direct interaction of the Rho GDP dissociation inhibitor with ezrin/radixin/moesin initiates the activation of the Rho small G protein. J Biol Chem 1997 Sep 12;272(37):23371-5 PMID: 9287351

Mammoto T, Yamamoto Y, Kagawa K, Hayashi Y, Mashimo T, Yoshiya I, Yamatodani A. Interactions between neuronal histamine and halothane anesthesia in rats. J Neurochem 1997 Jul;69(1):406-11 PMID: 9202335

Mammoto A, Masumoto N, Tahara M, Yoneda M, Nishizaki T, Tasaka K, Miyake A. Involvement of a sperm protein sensitive to sulfhydryl-depleting reagents in mouse sperm-egg fusion. J Exp Zool 1997 Jun 15;278(3):178-88 PMID: 9181696

Takada K, Hayashi Y, Kamibayashi T, Mammoto T, Yamatodani A, Kitamura S, Yoshiya I. The involvement of pertussis toxin-sensitive G proteins in the post receptor mechanism of central I1-imidazoline receptors. Br J Pharmacol 1997 Apr;120(8):1575-81 PMID: 9113381 PMCID: PMC1564637

1996

Masumoto N, Sasaki T, Tahara M, Mammoto A, Ikebuchi Y, Tasaka K, Tokunaga M, Takai Y, Miyake A. Involvement of Rabphilin-3A in cortical granule exocytosis in mouse eggs. J Cell Biol 1996 Dec;135(6 Pt 2):1741-7 PMID: 8991087 PMCID: PMC2133937

Mammoto A, Masumoto N, Tahara M, Ikebuchi Y, Ohmichi M, Tasaka K, Miyake A. Reactive oxygen species block sperm-egg fusion via oxidation of sperm sulfhydryl proteins in mice. Biol Reprod 1996 Nov;55(5):1063-8 PMID: 8902218

Tahara M, Tasaka K, Masumoto N, Mammoto A, Ikebuchi Y, Miyake A. Dynamics of cortical granule exocytosis at fertilization in living mouse eggs. Am J Physiol 1996 May;270(5 Pt 1):C1354-61 PMID: 8967435

Mammoto T, Kamibayashi T, Hayashi Y, Yamatodani A, Takada K, Yoshiya I. Antiarrhythmic action of rilmenidine on adrenaline-induced arrhythmia via central imidazoline receptors in halothane-anaesthetized dogs. Br J Pharmacol 1996 Apr;117(8):1744-8 PMID: 8732285 PMCID: PMC1909557

 1995

Yamaguchi M, Sakata M, Ogura K, Adachi K, Mammoto A, Miyake A. Inhibition of mouse placental lactogen-II release from placental cells by interleukin-1 after mid-pregnancy. J Endocrinol 1995 Dec;147(3):423-9 PMID: 8543912

Kamibayashi T, Hayashi Y, Mammoto T, Yamatodani A, Sumikawa K, Yoshiya I. Role of the vagus nerve in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs. Anesthesiology 1995 Nov;83(5):992-9 PMID: 7486186

Kamibayashi T, Mammoto T, Hayashi Y, Yamatodani A, Takada K, Sasaki S, Yoshiya I.

Further characterization of the receptor mechanism involved in the antidysrhythmic effect of dexmedetomidine on halothane/epinephrine dysrhythmias in dogs. Anesthesiology 1995 Nov;83(5):1082-9 PMID: 7486159

Yamaguchi M, Mammoto A, Taga T, Kishimoto T, Miyake A. Regulation of mouse soluble interleukin-6 receptor secretion by decidua. Biochem Biophys Res Commun 1995 Jun 26;211(3):1077-82 PMID: 7598695

Mizuki J, Masumoto N, Tahara M, Fukami K, Mammoto A, Tasaka K, Miyake A. Scanning electron microscope assessment of exocytotic changes in purified gonadotropes. J Endocrinol 1995 Feb;144(2):193-200 PMID: 7706972

Mammoto T, Kamibayashi T, Hayashi Y, Takada K, Yamatodani A, Yoshiya I. Rilmenidine prevents epinephrine-induced arrhythmias in halothane-anesthetized dogs. J Cardiovasc Pharmacol 1995;26 Suppl 2:S40-3 PMID: 8642804

Kamibayashi T, Hayashi Y, Mammoto T, Yamatodani A, Taenaka N, Yoshiya I. . Thoracic epidural anesthesia attenuates halothane-induced myocardial sensitization to dysrhythmogenic effect of epinephrine in dogs. Anesthesiology 1995 Jan;82(1):129-34 PMID: 7832294

1993

Hayashi Y, Sumikawa K, Yamatodani A, Kamibayashi T, Mammoto T, Kuro M. Quantitative analysis of pulmonary clearance of exogenous dopamine after cardiopulmonary bypass in humans. Anesth Analg 1993 Jan;76(1):107-12 PMID: 8418710

1992

Hayashi Y, Sumikawa K, Kamibayashi T, Yamatodani A, Mammoto T, Kuro M, Yoshiya I. Selective beta 1 and beta 2 adrenoceptor blockade on epinephrine-induced arrhythmias in halothane anaesthetized dogs. Can J Anaesth 1992 Oct;39(8):873-6 PMID: 1283841